| despechado | desperate |
| despecho | spite |
| despectivo | derogatory |
| despedazar | rend |
| despedida | farewell |
| despedida a la francesa | French leave |
| despedida de soltera | bachelorette party |
| despedida de soltero | bachelor party |
| despedir | discharge |
| Despega el transbordador espacial Discovery | Space Shuttle Discovery launches |
| Despega la sonda Phoenix con destino a Marte | Phoenix spacecraft launches towards Mars |
| despegado | indifferent |
| despegar | take off |
| despego | carelessness |
| despegue | blast-off |
| despeinadisimo | bed head |
| despeinado | untidy |
